Innovation and Patent Details

In all of the research and application by both doctors, the ECM (extracellular matrix) compositions in question act as a scaffold upon which new tissue forms to replace damaged or lost tissue. During the tissue re-growth process, the ECM is completely degraded and replaced with new tissue growth. This manner of treatment has been used successfully on both humans and animals.

Institution Where Invention/Innovation Developed

Purdue University

Name(s) of Inventor(s)/Innovator(s) - Title - Advanced Degrees Held

Dr. Stephen R. Badylak, D.V.M., PH.D., M.D.

Patent Number(s), Dates Issued, Patent Holder's Name

Purdue Patent

• Patent 5,554,389: Urinary bladder submucosa derived tissue graft; a tissue graft composition comprising bladder submucosal tissue delaminated from abluminal muscle layers and at least the luminal portion of the tunica mucosa of a segment of vertebrate urinary bladder is described. The graft composition can be implanted to replace or support damaged or diseased tissues.
• Filed: September 10, 1996
• Inventors: Dr. Stephen R. Badylak, Dr. Sherry L. Voytik, Dr. Andrew Brightman, Dr. Matt Waninger
• Assignee: Purdue Research Foundation
• Commercial Name: N/A

ACell Patent

• Patent 6,576,265: Tissue regenerative composition, method of making, and method of use thereof; a matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.
• Filed: October 18, 2000
• Inventor: Dr. Alan R. Spievack
• Assignee: ACell, Inc.
• Commercial Name: ACell Vet™

• Patent 6,579,538: Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof; a matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.
• Filed: October 18, 2000
• Inventor: Dr. Alan R. Spievack
• Assignee: ACell, Inc.
• Commercial Names: N/A