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Patent Number(s), Dates Issued, Patent Holder's Name

Emory Patents:

  • Patent 5,204,466: Method and compositions for the synthesis of BCH-189 and related compounds; the present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, .beta.-BCH-189 and related compounds. Furthermore, the stereochemistry at the nucleoside 4' position can be controlled to produce enantiomerically-enriched beta.-BCH-189 and its analogs.
  • Filed: February 1, 1990
  • Inventors: Dr. Dennis C. Liotta, Dr. Woo-Baeg Choi
  • Assignee: Emory University
  • Commercial Name: Epivir® (3TC)
  • Patent 5,210,085: Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds; the present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds.
  • Filed: February 22, 1991
  • Inventors: Dr. Dennis C Liotta, Dr. Raymond F Schinazi, Dr. Woo-Baeg Choi
  • Assignee: Emory University
  • Commercial Names: Coviracil®, Emtriva®
  • Patent 5,814,639: Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds; The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds.
  • Filed: February 16, 1993
  • Inventors: Dr. Dennis C. Liotta, Dr. Raymond F. Schinazi, Dr. Woo-Baeg Choi
  • Assignee: Emory University
  • Commercial Names: Coviracil®, Emtriva® (FTC)

BioChem Patents:

  • Patent 5,047,407: 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties; methods and compositions for preventing or treating human immunodeficiency virus (HIV) infections characterized by 2-substituted-5-substituted-1,3-oxathiolanes.
  • Filed: February 8, 1989
  • Inventors: Dr. Bernard Belleau, Dr. Nghe Nguyen-Ba
  • Assignee: BioChem International
  • Patent 5,151,426: 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties; methods and compositions for preventing or treating human immunodeficiency virus (HIV) infections characterized by 2- substituted-5-substituted-1,3-oxathiolanes.
  • Filed: June 17, 1991
  • Inventors: Dr. Bernard Belleau, Dr. Nghe Nguyen-Ba
  • Assignee: BioChem International
  • Patent 5,466,806: Processes for preparing substituted 1,3-oxathiolanes with antiviral properties; Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
  • Filed: March 29, 1993
  • Inventors: Dr. Bernard Belleau, Dr. Tarek Mansour, Dr. H.L. Allan Tse, Colleen A. Evans, Dr. Haolun Jin, Dr. Boulos Zacharie, Dr. Nghe Nguyen-Ba
  • Assignee: BioChem International
  • Patent 5,684,164: Processes for preparing substituted 1,3-oxathiolanes with antiviral properties; Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
  • Filed: June 6, 1995
  • Inventors: Dr. Bernard Belleau, Dr. Tarek Mansour, Dr. H.L. Allan Tse, Colleen A. Evans, Dr. Haolun Jin, Dr. Boulos Zacharie, Dr. Nghe Nguyen-Ba
  • Assignee: BioChem International

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